Endocrine Abstracts

Introduction: One of the autoimmune non–diabetic hypoglycemia (NDH) causes is the formation of antibodies to insulin (AB–IRI) or Hirata disease (HD).Objectives: To determine the prevalence of AB–IRI level increasing in patients with suspected NDH of various genesis and in healthy individuals.Methods: 96 patients aged 18–80 years with suspected NDH were included in prospective study. In all patients we determ...

Background and aims: To evaluate the level of tubular and glomerular biomarkers of kidney injury as potential nephroprorotective effects of GLP-1R agonist (liraglutide) addition in type 1 diabetic patients compared to standard insulin therapy.Materials and methods: 12 T1DM patients with normo-(AER <20 mg/l, n=7) and microalbuminuria (AER<199 mg/l, n=5) with liraglutide 1.2 mg as add on to insulin for 6 month and 12 patients with...

Background and aims: Microalbuminuria (MA) is not specific predictor of early stages of chronic kidney disease (CKD) in diabetes. We investigate several markers that might be useful in assessing early kidney damage in T1DM and T2DM patients additional to MA.Materials and methods: We examined 111 patients (T1DM/T2DM: 51/60) with AER<20 mg/l (n=80); <199 mg/l (n=18); ≥200 mg/l (n=13). Biomarkers of kidney damage (c...

Backgraund: The high incidence of cervical lymph nodes (LNs) metastasis in differentiated thyroid carcinoma (DTC) and lack of effective diagnostic tools determines the need for elaboration more specific tests.Aims: The aim of our study was to evaluate the accuracy and cut-off point of the thyroglobulin (Tg) in the washout fluid of fine-needle aspiration biopsy (FNA-Tg) in the diagnosis of DTC LNs metastasis.Materials and methods: A...

Introduction: Interaction between genetic and environmental factors is the foundation of the pathogenesis of autoimmune thyroiditis (AIT). One of the important factors is iodine supply. Iodine deficiency is the main cause of goiter, dysfunction of the thyroid gland, disorders of mental and physical development. Main solution of that problem is the iodine salt consumption. It can decrease iodine deficiency, but the RF doesn’t have general programs of salt iodization and ha...

Objectives: to study the response of calcium and phosphate homeostasis parameters to the cholecalciferol loading dose in patients with predialysis chronic kidney disease (CKD). Methods: We examined 17 patients with stage 3 CKD (CKD3) and 9 patients with stages 4–5 CKD (CKD4-5) without previously known disorders of mineral metabolism and intake of interfering drugs during last 3 months. The assessments included serum 25-hydroxyvitamin D (25(OH)D), free 25...